Difference: CellSorting (1 vs. 8)

Revision 82011-05-08 - RaquellHolmes

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META TOPICPARENT name="TeachingModules"

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Tool(s): MATLAB %EDITCELL{radio, 6, Virtual Cell , XPP, MATLAB, Gepasi, JWS online, Other}%
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Module Created: 2007/9/22 %EDITCELL{date, 10}%
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Abstract The Differential Adhesion Hypothesis was proposed by Steinberg (1963) as the basis for cell sorting during morphogenesis. Glazier and Graner (1992) developed models that explored the cellular mechanisms underlying cell sorting events. This module walks through creating a modeling experiment that explores the relationships between cell surface adhesion, random surface fluctuations and cell sorting.
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Model exercises  
Further readings Steinberg, 1963 Reconstruction of tissues by dissociated cells. Science 141 (3579) 401. Glazier and Graner, 1992 Simulation of the differential adhesion driven rearrangement of biological cells. Phys. Rev. 47 (3) 2128
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Revision 72011-03-03 - IonMoraru

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Revision 62009-11-25 - RaquellHOlmes

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META TOPICPARENT name="TeachingModules"

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Key Value
Module Name: Cell Sorting and Differential Adhesion
Author(s): Raquell M. Holmes and Mark Zajac %EDITCELL{text, 40}%
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Institution:  
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Institution: University Connecticut Health Center
 
Module Biology Topic: Development %EDITCELL{select,1, ,Cell Cycle, Circadian Rhythms, Biological Clocks, Biological Switches, Transcriptional Regulation, Translational Regulation, Cell Motility, Cytoskeleton, Cell Signaling, Development}%
Other Biology Topics:  
Keywords: Adhesion, morphogenesis, sorting %EDITCELL{text,40}%
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Model exercises  
Further readings Steinberg, 1963 Reconstruction of tissues by dissociated cells. Science 141 (3579) 401. Glazier and Graner, 1992 Simulation of the differential adhesion driven rearrangement of biological cells. Phys. Rev. 47 (3) 2128
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Model files and exercises

Feature Name Description
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Model exercises Name attach files
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Revision 52009-11-18 - KhanhNguyen

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META TOPICPARENT name="TeachingModules"

Teaching Module Description

Describe a module by using the Edit button to enter information
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Key Value
Module Name: Cell Sorting and Differential Adhesion
Author(s): Raquell M. Holmes and Mark Zajac %EDITCELL{text, 40}%
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Institution:  
 
Module Biology Topic: Development %EDITCELL{select,1, ,Cell Cycle, Circadian Rhythms, Biological Clocks, Biological Switches, Transcriptional Regulation, Translational Regulation, Cell Motility, Cytoskeleton, Cell Signaling, Development}%
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Other Biology Topics:  
 
Keywords: Adhesion, morphogenesis, sorting %EDITCELL{text,40}%
UG Course Level: Intermediate %EDITCELL{radio,3, Beginner, Intermediate, Advanced}%
Tool(s): MATLAB %EDITCELL{radio, 6, Virtual Cell , XPP, MATLAB, Gepasi, JWS online, Other}%
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Abstract The Differential Adhesion Hypothesis was proposed by Steinberg (1963) as the basis for cell sorting during morphogenesis. Glazier and Graner (1992) developed models that explored the cellular mechanisms underlying cell sorting events. This module walks through creating a modeling experiment that explores the relationships between cell surface adhesion, random surface fluctuations and cell sorting.
Physiology Cell Adhesion, membrane ruffling/fluctuations
Model description The model tests the hypothesis that differential adhesion is responsible or sufficient for cell sorting. The experiments associated with this model made use of neural and pigmented cells isolated from chick embryo retina. These cells have distinguishable adhesion properties and when mixed will sort themselves into two separate populations. The model takes into account cells having different degrees of "stickiness", cell shapes, surface fluctuations and random exploration of local environments. The model is described in physical terms of energy costs, local and global minima, and boltzman state transitions.
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Highlights Developmental biology: morphogenesis, cell sorting, differential adhesion; Physics: Boltzman state transitions, Potts model, energy costs; Computer Science: lattice, arrays, linked lists.
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Model files Developmental biology: morphogenesis, cell sorting, differential adhesion; Physics: Boltzman state transitions, Potts model, energy costs; Computer Science: lattice, arrays, linked lists.
Model exercises  
 
Further readings Steinberg, 1963 Reconstruction of tissues by dissociated cells. Science 141 (3579) 401. Glazier and Graner, 1992 Simulation of the differential adhesion driven rearrangement of biological cells. Phys. Rev. 47 (3) 2128

Model files and exercises

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Model files enter file names description
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Revision 42009-09-08 - RaquellHOlmes

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META TOPICPARENT name="TeachingModules"

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Module Created: 2007/9/22 %EDITCELL{date, 10}%
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Abstract The Differential Adhesion Hypothesis was proposed by Steinberg (1963) as the basis for cell sorting during morphogenesis. Glazier and Graner (1992) developed models that explored the cellular mechanisms underlying cell sorting events. This module walks through creating a modeling experiment that explores the relationships between cell surface adhesion, random surface fluctuations and cell sorting.
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Model files enter file names description
Model exercises Name attach files
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Attach additional files for the module by using the red Attach link below
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Attach additional files for the module by using the red Attach link below
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Revision 32008-05-07 - RaquellHOlmes

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META TOPICPARENT name="TeachingModules"

Teaching Module Description

Describe a module by using the Edit button to enter information
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Key Value
Module Name: Cell Sorting and Differential Adhesion
Author(s): Raquell M. Holmes and Mark Zajac %EDITCELL{text, 40}%
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Module Biology Topic: %EDITCELL{select,1, ,Cell Cycle, Circadian Rhythms, Biological Clocks, Biological Switches, Transcriptional Regulation, Translational Regulation, Cell Motility, Cytoskeleton, Cell Signaling}%
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Module Biology Topic: Development %EDITCELL{select,1, ,Cell Cycle, Circadian Rhythms, Biological Clocks, Biological Switches, Transcriptional Regulation, Translational Regulation, Cell Motility, Cytoskeleton, Cell Signaling, Development}%
 
Keywords: Adhesion, morphogenesis, sorting %EDITCELL{text,40}%
UG Course Level: Intermediate %EDITCELL{radio,3, Beginner, Intermediate, Advanced}%
Tool(s): MATLAB %EDITCELL{radio, 6, Virtual Cell , XPP, MATLAB, Gepasi, JWS online, Other}%
Other tool: Edit to Insert Name and URL for Tool %EDITCELL{text, 50}%
Module Created: 2007/9/22 %EDITCELL{date, 10}%
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Abstract The Differential Adhesion Hypothesis was proposed by Steinberg (1963) as the basis for cell sorting during morphogenesis. Glazier and Graner (1992) developed models that explored the cellular mechanisms underlying cell sorting events. This module walks through creating a modeling experiment that explores the relationships between cell surface adhesion, random surface fluctuations and cell sorting.
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Physiology Cell Adhesion
Model description Describe model
Model files enter file names and description-this wants two columns
Model exercises attach files
Highlights text area
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Physiology Cell Adhesion, membrane ruffling/fluctuations
Model description The model tests the hypothesis that differential adhesion is responsible or sufficient for cell sorting. The experiments associated with this model made use of neural and pigmented cells isolated from chick embryo retina. These cells have distinguishable adhesion properties and when mixed will sort themselves into two separate populations. The model takes into account cells having different degrees of "stickiness", cell shapes, surface fluctuations and random exploration of local environments. The model is described in physical terms of energy costs, local and global minima, and boltzman state transitions.
Highlights Developmental biology: morphogenesis, cell sorting, differential adhesion; Physics: Boltzman state transitions, Potts model, energy costs; Computer Science: lattice, arrays, linked lists.
 
Further readings Steinberg, 1963 Reconstruction of tissues by dissociated cells. Science 141 (3579) 401. Glazier and Graner, 1992 Simulation of the differential adhesion driven rearrangement of biological cells. Phys. Rev. 47 (3) 2128
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Model files and exercises

Feature Name Description
Model files enter file names description
Model exercises Name attach files
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CategoryModule

Revision 22008-03-21 - RaquellHOlmes

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META TOPICPARENT name="TeachingModules"

Teaching Module Description

Describe a module by using the Edit button to enter information

Key Value
Module Name: Cell Sorting and Differential Adhesion
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Author(s): Mark Zajac and Raquell M. Holmes %EDITCELL{text, 40}%
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Author(s): Raquell M. Holmes and Mark Zajac %EDITCELL{text, 40}%
 
Module Biology Topic: %EDITCELL{select,1, ,Cell Cycle, Circadian Rhythms, Biological Clocks, Biological Switches, Transcriptional Regulation, Translational Regulation, Cell Motility, Cytoskeleton, Cell Signaling}%
Keywords: Adhesion, morphogenesis, sorting %EDITCELL{text,40}%
UG Course Level: Intermediate %EDITCELL{radio,3, Beginner, Intermediate, Advanced}%
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Module Created: 2007/9/22 %EDITCELL{date, 10}%

Module

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Abstract Differential adhesion was proposed as a mechanism for cell sorting (ref). One method of obtaining support for this hypothesis was modeling. A modeling experiment that can be designed to address the question are different adhesive properties and random movement sufficient to explain cell sorting.
Physiology textarea, 80x5
Model description textarea, 80x3
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Abstract The Differential Adhesion Hypothesis was proposed by Steinberg (1963) as the basis for cell sorting during morphogenesis. Glazier and Graner (1992) developed models that explored the cellular mechanisms underlying cell sorting events. This module walks through creating a modeling experiment that explores the relationships between cell surface adhesion, random surface fluctuations and cell sorting.
Physiology Cell Adhesion
Model description Describe model
 
Model files enter file names and description-this wants two columns
Model exercises attach files
Added:
>
>
Highlights text area
Further readings Steinberg, 1963 Reconstruction of tissues by dissociated cells. Science 141 (3579) 401. Glazier and Graner, 1992 Simulation of the differential adhesion driven rearrangement of biological cells. Phys. Rev. 47 (3) 2128
 Attach additional files for the module by using the red Attach link below

CategoryModule

Revision 12008-03-14 - RaquellHOlmes

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Added:
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META TOPICPARENT name="TeachingModules"

Teaching Module Description

Describe a module by using the Edit button to enter information

Key Value
Module Name: Cell Sorting and Differential Adhesion
Author(s): Mark Zajac and Raquell M. Holmes
Module Biology Topic:  
Keywords: Adhesion, morphogenesis, sorting
UG Course Level: Intermediate
Tool(s): MATLAB
Other tool: Edit to Insert Name and URL for Tool
Module Created: 2007/9/22
<-- /editTable -->

Module

key value
Abstract Differential adhesion was proposed as a mechanism for cell sorting (ref). One method of obtaining support for this hypothesis was modeling. A modeling experiment that can be designed to address the question are different adhesive properties and random movement sufficient to explain cell sorting.
Physiology textarea, 80x5
Model description textarea, 80x3
Model files enter file names and description-this wants two columns
Model exercises attach files
<-- /editTable -->
Attach additional files for the module by using the red Attach link below

CategoryModule

-- RaquellHOlmes - 14 Mar 2008

 
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