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2008 All-Hands Meeting Bethesda Marriott March 20-21, 2008


Thursday, March 20

8:00-8:30 a.m. Registration and Light Refreshments

8:30-8:45 a.m. Welcome, logistics, program update Doug Sheeley, NCRR

8:45 a.m. Overview of the NCDIR: from Proteomic Data to Macromolecular Structures John Aitchison, Institute for Systems Biology

9:10 a.m. Late Processing and Nuclear Export of Large Ribonucleoprotein Complexes Marlene Oeffinger, Rockefeller University

9:35 9:35 a.m. IMP: Software for Integrative Determination of Macromolecular Assembly Structures Daniel Russel, UCSF

10:00 a.m. Revealing the HIV-Host Interactome Mark Muesing, Aaron Diamond AIDS Research Center

10:25-10:55 a.m. Break, Poster Viewing

10:55 a.m. Identification of Novel Proteolytic Pathways with Proteomics Guy Salvesen, The Burnham Institute for Medical Research

11:20 a.m. Applying the CPP methodologies to anti-viral and anti-bacterial drug design Alex Strongin, The Burnham Institute for Medical Research

11:45 a.m. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease Bonnie Sloane, Wayne State University

12:10 p.m. Predicting unknown Proteolytic Pathways: Charting new Research Directions Jeffrey W. Smith, The Burnham Institute for Medical Research

12:35- 2:00 p.m. Working Lunch for Registered Participants: Discussion of the TCNP Program: How can we improve the program going forward?

2:00 p.m. Massive mutagenesis of histones H3 and H4 Jef Boeke, Johns Hopkins

2:25 p.m. Global analysis of protein functions using a protein chip approach Heng Zhu, Johns Hopkins

2:50 p.m. Multi-scale systems analysis of chromatin structure Joel Bader, Johns Hopkins

2008 All-Hands Meeting Bethesda Marriott March 20-21, 2008


Thursday, March 20

3:15 p.m. Structural and biochemical analysis of the histone demethylase LSD1 Hongtao Yu, University of Texas Southwestern Medical Center

3:40-4:10 p.m. Break, Poster Viewing

4:10 p.m. Application of TCNP technologies to understand polarity in cell-cell fusion William Mohler, UCHC

4:35 p.m. Bringing new TCNP technologies to the education and research communities Raquell Holmes, UCHC

5:00-7:00 p.m. Adjourn for Dinner (on your own)

7:00-9:30 p.m. Poster Session

2008 All-Hands Meeting Bethesda Marriott March 20-21, 2008


Friday, March 21

8:00-8:30 a.m. Registration and Light Refreshments

8:30 a.m. Biosensor platform development at the Fluorescent Probes and Imaging TCNP. Alan Waggoner, Carnegie Mellon University

8:55 a.m. Development of protease biosensors. Peter Berget and Crystal Falco, Carnegie Mellon University

9:20 a.m. Biosensors for endocytosis and exocytosis based on novel Fluorogen Activating Peptides and Fluorogens Marcel Bruchez, Greg Fisher, Anmol Grover, John Holleran, Sally Adler, James Fitzpatrick, Jon Jarvik, Paul Johnston and John Lazo, Carnegie Mellon University and University of Pittsburgh

9:45 a.m. Analysis of microtubule ends in living regulatory mutants Estelle Glory, Rebecca Webb, Robert F. Murphy and Brooke McCartney Carnegie Mellon University

10:10-10:30 am Break, Poster Viewing

10:30 a.m. Applications of scFv based biosensors in immunology. Russell Salter and Simon Watkins, University of Pittsburgh

10:55 a.m. "New technologies for modeling stochastic processes and diffusion in crowded spaces" Boris Slepchenko, UCHC

11:20 a.m. A new method to measure translational output from individual RNA molecules in live neurons using single molecule imaging John Carson, UCHC

11:45 a.m. Signaling platforms: manipulating the local concentration of signaling proteins in living cells BruceMayerBruce Mayer, UCHC

12:10-1:30 p.m. Working Lunch for Registered Participants Discussion of Inter-TCNP Collaboration

Integration of PSLID and SLIF with “Virtual Cell” Robert F. Murphy, Les Loew and Ion Moraru Carnegie Mellon University and University of Connecticut Virtual geometries for spatial modeling of networks and pathways Ion Moraru, UCHC

2008 All-Hands Meeting Bethesda Marriott March 20-21, 2008


Friday, March 21

1:30 p.m. Regulation of spatial domains of signaling components by cell shape Susana Neves, Mount Sinai School of Medicine

1:55 p.m. Integrating Virginia Tech and UCHC Technologies for Cell Cycle Modeling Cliff Shaffer, Virginia Tech

2:20 p.m. TBD Ileana Cristea, Princeton University

2:45 p.m. Analysis of signaling pathways in cancers using quantitative mass spectrometry Akhilesh Pandey, Johns Hopkins and Harold Varmus and Ugay Guha, Sloan Kettering

3:10 p.m. Closing Remarks

3:15 p.m. Adjourn

Topic attachments
I Attachment Action Size Date Who Comment
PDFpdf AITCHISON_NCDIR.pdf manage 4849.0 K 2008-04-15 - 17:05 KemBoddie John_Aitchison
PDFpdf Alex_Strongin.pdf manage 2599.1 K 2008-04-15 - 17:09 KemBoddie Alex_Strongin
PDFpdf Bonnie_Sloane.pdf manage 1311.8 K 2008-04-15 - 17:10 KemBoddie Bonnie_Sloane
PDFpdf Boris_Slepchenko.pdf manage 1108.0 K 2008-04-15 - 17:15 KemBoddie Boris_Slepchenko
PDFpdf Bruce_Mayer.pdf manage 3433.4 K 2008-04-15 - 17:16 KemBoddie Bruce_Mayer
PDFpdf Cliff_Shaffer.pdf manage 2992.8 K 2008-04-15 - 17:18 KemBoddie Cliff_Shaffer
PDFpdf Daniel_Russel,_Sali_IMP=_2008_TCNP_All_Hands_Mtg..pdf manage 22838.8 K 2008-04-15 - 17:07 KemBoddie Daniel_Russel
PDFpdf Estelle_Glory.pdf manage 1565.7 K 2008-04-15 - 17:13 KemBoddie Estelle_Glory
PDFpdf Guy_Salvesen.pdf manage 472.5 K 2008-04-15 - 17:09 KemBoddie Guy_Salvesen
PDFpdf John_Carson.pdf manage 440.5 K 2008-04-15 - 17:16 KemBoddie John Carson
PDFpdf Marcel_Bruchez.pdf manage 3704.5 K 2008-04-15 - 17:13 KemBoddie Marcel_Bruchez
PDFpdf Marlene_Oeffinger.pdf manage 1892.5 K 2008-04-15 - 17:06 KemBoddie Marlene_Oeffinger
PDFpdf Peter_Berget.pdf manage 1391.1 K 2008-04-15 - 17:12 KemBoddie Peter_Berget
PDFpdf Raquell_Holmes.pdf manage 2707.5 K 2008-04-15 - 17:11 KemBoddie Raquell_Holmes
PDFpdf Simon_Watkins.pdf manage 10142.0 K 2008-04-15 - 17:14 KemBoddie Simon_Watkins
PDFpdf TCNP_Agenda.pdf manage 123.8 K 2008-04-15 - 17:03 KemBoddie TCNP Agenda
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Topic revision: r5 - 2008-04-15 - 20:28:31 - KemBoddie
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